Texas A&M University School of Law is organizing and hosting a conference on the United States-Mexico-Canada Agreement (USMCA). The USMCA, which still must be approved by the respective country legislative branches, varies markedly from its predecessor, NAFTA, in its investment, environment and labor chapters, and treatment of automotive rules of origin, financial services and regulation, dispute resolution, energy, digital trade and intellectual property. Whether approved or not, negotiating the USMCA marks a new era in North American relations and raises important questions about the future of international trade, global institutions, and regionalism.